234 research outputs found
Spectroscopy and Time Variability of Absorption Lines in the Direction of the Vela Supernova Remnant
We present high resolution (R~75,000), high signal-to-noise (S/N~100) Ca II
3933.663 and Na I 5889.951, 5895.924 spectra of 68
stars in the direction of the Vela supernova remnant. The spectra comprise the
most complete high resolution, high S/N, optical survey of early type stars in
this region of the sky. A subset of the sight lines has been observed at
multiple epochs, 1993/1994 and 1996. Of the thirteen stars observed twice,
seven have spectra revealing changes in the equivalent width and/or velocity
structure of lines, most of which arise from remnant gas. Such time variability
has been reported previously for the sight lines towards HD 72089 and HD 72997
by Danks & Sembach (1995) and for HD 72127 by Hobbs et al. (1991). We have
confirmed the ongoing time variability of these spectra and present new
evidence of variability in the spectra of HD 73658, HD 74455, HD 75309 and HD
75821. We have tabulated Na I and Ca II absorption line information for the
sight lines in our sample to serve as a benchmark for further investigations of
the dynamics and evolution of the Vela SNR.Comment: 8 pages of text, 4 tables, 16 pages of figures Accepted and to be
published in ApJ
FUSE Measurements of Far Ultraviolet Extinction. I. Galactic Sight Lines
We present extinction curves that include data down to far ultraviolet
wavelengths (FUV; 1050 - 1200 A) for nine Galactic sight lines. The FUV
extinction was measured using data from the Far Ultraviolet Spectroscopic
Explorer. The sight lines were chosen for their unusual extinction properties
in the infrared through the ultraviolet; that they probe a wide range of dust
environments is evidenced by the large spread in their measured ratios of
total-to-selective extinction, R_V = 2.43 - 3.81. We find that extrapolation of
the Fitzpatrick & Massa relationship from the ultraviolet appears to be a good
predictor of the FUV extinction behavior. We find that predictions of the FUV
extinction based upon the Cardelli, Clayton & Mathis (CCM) dependence on R_V
give mixed results. For the seven extinction curves well represented by CCM in
the infrared through ultraviolet, the FUV extinction is well predicted in three
sight lines, over-predicted in two sight lines, and under-predicted in 2 sight
lines. A Maximum Entropy Method analysis using a simple three component grain
model shows that seven of the nine sight lines in the study require a larger
fraction of grain materials to be in dust when FUV extinction is included in
the models. Most of the added grain material is in the form of small (radii <
200 A) grains.Comment: Accepted for publication in the Astrophysical Journal. 31 pages with
7 figure
An Analysis of the Shapes of Interstellar Extinction Curves. V. The IR-Through-UV Curve Morphology
We study the IR-through-UV interstellar extinction curves towards 328
Galactic B and late-O stars. We use a new technique which employs stellar
atmosphere models in lieu of unreddened "standard" stars. This technique is
capable of virtually eliminating spectral mismatch errors in the curves. It
also allows a quantitative assessment of the errors and enables a rigorous
testing of the significance of relationships between various curve parameters,
regardless of whether their uncertainties are correlated. Analysis of the
curves gives the following results: (1) In accord with our previous findings,
the central position of the 2175 A extinction bump is mildly variable, its
width is highly variable, and the two variations are unrelated. (2) Strong
correlations are found among some extinction properties within the UV region,
and within the IR region. (3) With the exception of a few curves with extreme
(i.e., large) values of R(V), the UV and IR portions of Galactic extinction
curves are not correlated with each other. (4) The large sightline-to-sightline
variation seen in our sample implies that any average Galactic extinction curve
will always reflect the biases of its parent sample. (5) The use of an average
curve to deredden a spectral energy distribution (SED) will result in
significant errors, and a realistic error budget for the dereddened SED must
include the observed variance of Galactic curves. While the observed large
sightline-to-sightline variations, and the lack of correlation among the
various features of the curves, make it difficult to meaningfully characterize
average extinction properties, they demonstrate that extinction curves respond
sensitively to local conditions. Thus, each curve contains potentially unique
information about the grains along its sightline.Comment: To appear in the Astrophysical Journal, Part 1, July 1, 2007. Figures
and Tables which will appear only in the electronic version of the Journal
can be obtained via anonymous ftp from ftp://ftp.astronomy.villanova.edu .
After logging in, change directories to "fitz/FMV_EXTINCTION". A README file
describes the various files present in the director
Orally active antischistosomal early leads identified from the open access malaria box.
BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs. METHODOLOGY: We studied the antischistosomal properties of the Medicines for Malaria Venture (MMV) malaria box containing 200 diverse drug-like and 200 probe-like compounds with confirmed in vitro activity against Plasmodium falciparum. Compounds were tested against schistosomula and adult Schistosoma mansoni in vitro. Based on in vitro performance, available pharmacokinetic profiles and toxicity data, selected compounds were investigated in vivo. PRINCIPAL FINDINGS: Promising antischistosomal activity (IC50: 1.4-9.5 µM) was observed for 34 compounds against schistosomula. Three compounds presented IC50 values between 0.8 and 1.3 µM against adult S. mansoni. Two promising early leads were identified, namely a N,N'-diarylurea and a 2,3-dianilinoquinoxaline. Treatment of S. mansoni infected mice with a single oral 400 mg/kg dose of these drugs resulted in significant worm burden reductions of 52.5% and 40.8%, respectively. CONCLUSIONS/SIGNIFICANCE: The two candidates identified by investigating the MMV malaria box are characterized by good pharmacokinetic profiles, low cytotoxic potential and easy chemistry and therefore offer an excellent starting point for antischistosomal drug discovery and development
Galactic Structure Toward the Carina Tangent
This investigation presents a photometric study of the Galactic structure
toward the Carina arm tangent. The field is located between 280 deg and 286 deg
galactic longitude and -4 deg to 4 deg galactic latitude. All currently
available uvbybeta data is used to obtain homogeneous color excesses and
distances for more than 260 stars of spectral types O to G. We present revised
distances and average extinction for the open clusters and cluster candidates
NGC 3293, NGC 3114, Loden 46 and Loden 112. The cluster candidate Loden 112
appears to be a very compact group at a true distance modulus of 11.06 +\- 0.11
(s.e.) (1629 +84,-80 pc), significantly closer than previous estimates. We
found other OB stars at that same distance and, based on their proper motions,
suggest a new OB association at coordinates 282 deg < l < 285 deg, -2 deg < b <
2 deg. Utilizing BV photometry and spectral classification of the known O-type
stars in the very young open cluster Wd 2 we provide a new distance estimate of
14.13 +\-0.16 (s.e.) (6698 +512,-475 pc), in excellent agreement with recent
distance determinations to the giant molecular structures in this direction. We
also discuss a possible connection between the HII region RCW 45 and the
highly-reddened B+ star CPD -55 3036 and provide a revised distance for the
luminous blue variable HR Car.Comment: accepted to PAS
UBVI and Ha Photometry of the h & chi Persei cluster
UBVI and Ha photometry is presented for 17319 stars in vicinity of the young
double cluster h & chi Persei. Our photometry extends over a 37arcmin x 1arcdeg
field centered on the association. We construct reddening contours within the
imaged field. We find that the two clusters share a common distance modulus of
11.750.05 and ages of log age(yr) = 7.10.1. From the V-Ha colour, a
measure of the Ha emission strength, we conduct a survey for emission line
objects within the association. We detect a sample of 33 Be stars, 8 of which
are new detections. We present a scenario of evolutionary enhancement of the Be
phenomenon to account for the peak in Be fraction towards the top of the
main-sequence in the population of h & chi Persei and similar young clusters.Comment: 20 pages, 9 figures, AJ Jul
VarGoats project: a dataset of 1159 whole-genome sequences to dissect Capra hircus global diversity
Background: Since their domestication 10,500 years ago, goat populations with distinctive genetic backgrounds have adapted to a broad variety of environments and breeding conditions. The VarGoats project is an international 1000-genome resequencing program designed to understand the consequences of domestication and breeding on the genetic diversity of domestic goats and to elucidate how speciation and hybridization have modeled the genomes of a set of species representative of the genus Capra. Findings: A dataset comprising 652 sequenced goats and 507 public goat sequences, including 35 animals representing eight wild species, has been collected worldwide. We identified 74,274,427 single nucleotide polymorphisms (SNPs) and 13,607,850 insertion-deletions (InDels) by aligning these sequences to the latest version of the goat reference genome (ARS1). A Neighbor-joining tree based on Reynolds genetic distances showed that goats from Africa, Asia and Europe tend to group into independent clusters. Because goat breeds from Oceania and Caribbean (Creole) all derive from imported animals, they are distributed along the tree according to their ancestral geographic origin. Conclusions: We report on an unprecedented international effort to characterize the genome-wide diversity of domestic goats. This large range of sequenced individuals represents a unique opportunity to ascertain how the demographic and selection processes associated with post-domestication history have shaped the diversity of this species. Data generated for the project will also be extremely useful to identify deleterious mutations and polymorphisms with causal effects on complex traits, and thus will contribute to new knowledge that could be used in genomic prediction and genome-wide association studies
Atomic super-resolution tomography
We consider the problem of reconstructing a nanocrystal at atomic resolution from electron microscopy images taken at a few tilt angles. A popular reconstruction approach called discrete tomography confines the atom locations to a coarse spatial grid, which is inspired by the physical a priori knowledge that atoms in a crystalline solid tend to form regular lattices. Although this constraint has proven to be powerful for solving this very under-determined inverse problem in many cases, its key limitation is that, in practice, defects may occur that cause atoms to deviate from regular lattice positions. Here we propose a grid-free discrete tomography algorithm that allows for continuous deviations of the atom locations similar to super-resolution approaches for microscopy. The new formulation allows us to define atomic interaction potentials explicitly, which results in a both meaningful and powerful incorporation of the available physical a priori knowledge about the crystal's properties. In computational experiments, we compare the proposed grid-free method to established grid-based approaches and show that our approach can indeed recover the atom positions more accurately for common lattice defects
The p.V37I Exclusive Genotype Of GJB2: A Genetic Risk-Indicator of Postnatal Permanent Childhood Hearing Impairment
Postnatal permanent childhood hearing impairment (PCHI) is frequent (0.25%–0.99%) and difficult to detect in the early stage, which may impede the speech, language and cognitive development of affected children. Genetic tests of common variants associated with postnatal PCHI in newborns may provide an efficient way to identify those at risk. In this study, we detected a strong association of the p.V37I exclusive genotype of GJB2 with postnatal PCHI in Chinese Hans (P = 1.4×10−10; OR 62.92, 95% CI 21.27–186.12). This common genotype in Eastern Asians was present in a substantial percentage (20%) of postnatal PCHI subjects, and its prevalence was significantly increased in normal-hearing newborns who failed at least one newborn hearing screen. Our results indicated that the p.V37I exclusive genotype of GJB2 may cause subclinical hearing impairment at birth and increases risk for postnatal PCHI. Genetic testing of GJB2 in East Asian newborns will facilitate prompt detection and intervention of postnatal PCHI
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